8 Jun 2017 http://InjectingAluminum.comDr. Romain Gerard"Note that aluminum hydroxide became available in 1927. The same compound that is used in

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“Although GAD vaccine was ineffective in recent-onset diabetes, the vaccine might be beneficial for prevention of type 1 diabetes if given earlier in the course of disease, or could be a Glutamic acid decarboxylase (GAD)-alum (Diamyd(®), Diamyd Medical, Stockholm, Sweden) is an adjuvant-formulated vaccine incorporating recombinant human GAD65, the specific isoform of GAD expressed in human pancreatic β-cells and a major antigen targeted by autoreactive T lymphocytes in Type 1 diabet … Aims/hypothesis: A European Phase III trial of GAD formulated with aluminium hydroxide (GAD-alum) failed to reach its primary endpoint (preservation of stimulated C-peptide secretion from baseline to 15 months in type 1 diabetes patients), but subgroup analysis showed a clinical effect when participants from Nordic countries were excluded, raising concern as to whether the mass vaccination of the Swedish and Finnish populations with the Pandemrix influenza vaccine could have influenced the Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes. GAD65-specific immunotherapy has a significant effect on C-peptide retention in individuals with recent-onset type 1 diabetes who have the DR3-DQ2 haplotype. Graphical abstract. Aims/hypothesis A European Phase III trial of GAD formulated with aluminiumhydroxide (GAD-alum) failed to reach its primary endpoint (preservation of stimulated C-peptide secretion from baseline to 15 months in type 1 diabetes patients), but subgroup analysis showed a clinical effect when participants from Nordic countries were excluded, raising concern as to whether the mass vaccination of the Swedish and Finnish populations with the Pandemrix influenza vaccine could have influenced the GAD-alum dose or planned vaccinations up to 2 months after thelastGAD-aluminjectionwerenotpermitted,withtheexcep-tion of influenza vaccination. We have previously shown that GAD-alum has a specific immunomodulatory effect, indicated by enhanced GAD autoantibodies (GADA) and specific in vitro cytokine secretion upon GAD 65 stimulation [15, 16].

Gad-alum vaccine

One strategy employs GAD65 conjugated to aluminium hydroxide (GAD-alum) to take advantage of the T helper (Th)2-biasing adjuvant properties of alum and thereby regulate pathological Th1 autoimmunity. Aims/hypothesis A European Phase III trial of GAD formulated with aluminiumhydroxide (GAD-alum) failed to reach its primary endpoint (preservation of stimulated C-peptide secretion from baseline to 15 months in type 1 diabetes patients), but subgroup analysis showed a clinical effect when participants from Nordic countries were excluded, raising concern as to whether the mass vaccination of the Swedish and Finnish populations with the Pandemrix influenza vaccine could have influenced the Earlier this fall, Phase IIb topline results of the DIAGNODE-2 trial demonstrated a potential type 1 diabetes vaccine GAD-alum — an immunomodulating antigen-specific therapy – had a highly significant and clinically relevant effect in genetically defined subgroups of individuals with the disease. Diamyd Medical is supporting the trials and Individuals with a longer period between influenza vaccination and GAD-alum administration had higher GAD autoantibody levels, higher GAD-induced Th2 cytokines and reduced C-peptide decline compared with those who were vaccinated close to GAD-alum therapy (as summarised in Fig. 1). GAD-alum denotes the recombinant human 65-kD isoform of glutamic acid decarboxylase in a standard vaccine formulation with alum. All but one patient received two doses of either GAD-alum or GAD is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. Randomised controlled clinical trials of a GAD + alum vaccine in human participants have so far given conflicting results.

27 Oct 2015 In my opinion, aluminum adjuvant is far more likely to be the cause. This is not to say that I think mercury is safe. Its definitely not. It causes some

“These results support decades of research on GAD-alum as a safe, specific and efficacious treatment for type 1 diabetes, says Johnny Ludvigsson, Professor at Linköping University. “A strong scientific and clinical rational makes me confident that we are now able to make a significant positive impact for individuals with type 1 diabetes”. An open label investigator initiated clinical trial, where Diamyd ® (GAD-alum) is administered directly into lymph nodes with oral supplements of vitamin D. The purpose of the trial is to evaluate the safety of intralymphatic treatment with Diamyd ® in LADA patients and the effectiveness of preserving the insulin producing capacity. Several trials betted on GAD65 as key Ag and on different routes: Dyamid, a GAD-Alum vaccine, was administered subcutaneous in recent onset T1D (15, 16) and in adults with latent autoimmune diabetes (LADA) without achievement of clinically desirable results .

Aims/hypothesis: A European Phase III trial of GAD formulated with aluminium hydroxide (GAD-alum) failed to reach its primary endpoint (preservation of stimulated C-peptide secretion from baseline to 15 months in type 1 diabetes patients), but subgroup analysis showed a clinical effect when participants from Nordic countries were excluded, raising concern as to whether the mass vaccination of the Swedish and Finnish populations with the Pandemrix influenza vaccine could have influenced the

By administering excess autoantigen, the body may stop its attack on its own cells that produce insulin. controlled clinical trials of a GAD+alum vaccine in human participants have so far given conflicting results. Methods In this study, we sought to see whether a clearer answer to the question of whether GAD65 has an effect on C-peptide could be reached by combining individual-level data from the randomised controlled trials using Bayesian Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) has published results from a meta study that demonstrates a highly significant and clinically relevant effect of Diamyd Medical’s lead drug candidate Diamyd ® (GAD-alum) on preserving endogenous insulin production in genetically defined subgroups of type 1 diabetes.

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet. The subjects had been previously enrolled in Type 1 Diabetes TrialNet protocols TN02 MMF/DZB (n = 14), TN08 GAD-Alum Vaccine (n = 15), TN09 CTLA4 (n = 15), and TN14 anti-IL1β (n = 10).
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Gadiformes immunization. immunize. immunized.

In the group that received two doses of GAD-alum, levels of several GAD65-induced cytokines were higher in participants who received the H1N1 vaccination and the first GAD-alum injection at least 150 days apart, and the change in fasting and stimulated C-peptide at 15 months was associated with the relative time between vaccines. Antigen-specific therapy aims to modify inflammatory T cell responses in type 1 diabetes and restore immune tolerance. One strategy employs GAD65 conjugated to aluminium hydroxide (GAD-alum) to take advantage of the T helper (Th)2-biasing adjuvant properties of alum and thereby regulate pathological Th1 autoimmunity.
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C: Putative benefit in a small subgroup (those treated within 6 months of diagnosis) in a GAD-alum vaccine trial. (24) that was not confirmed in two larger trials (D

All This therapeutic pathway provides a safe treatment to preserve beta cell function in new-onset diabetic individuals with the GAD-Alum vaccine being the most extensively studied therapy. Insulin is being used in many forms to prevent diabetes and stop the underlying autoimmune process. AIMS/HYPOTHESIS:A European Phase III trial of GAD formulated with aluminium hydroxide (GAD-alum) failed to reach its primary endpoint (preservation of stimulated C-peptide secretion from baseline to 15 months in type 1 diabetes patients), but subgroup analysis showed a clinical effect when participants from Nordic countries were excluded, raising concern as to whether the mass vaccination of the Swedish and Finnish populations with the Pandemrix influenza vaccine could have influenced the "These results support decades of research on GAD-alum as a safe, specific and efficacious treatment for type 1 diabetes, says Johnny Ludvigsson, Professor at Linköping University. Several trials betted on GAD65 as key Ag and on different routes: Dyamid, a GAD-Alum vaccine, was administered subcutaneous in recent onset T1D (15, 16) and in adults with latent autoimmune diabetes (LADA) without achievement of clinically desirable results .

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Administration Route on the Effect of GAD-specific Immunotherapy O2: Johnny based study of infection, hospitalization, vaccination and mortality. O10: Vera Vik Bjarkø: diabetes patients receiving GAD-alum injection into the lymph node

43-49 Article in journal (Refereed) Published Abstract [en] GAD is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. Randomised controlled clinical trials of a GAD + alum vaccine in human participants have so far given conflicting results. Several trials betted on GAD65 as key Ag and on different routes: Dyamid, a GAD-Alum vaccine, was administered subcutaneous in recent onset T1D (15, 16) and in adults with latent autoimmune diabetes (LADA) without achievement of clinically desirable results . Diamyd Medical today announced the topline results from the placebo-controlled Phase IIb trial DIAGNODE-2, where the diabetes vaccine Diamyd ® (GAD-alum) was injected directly into a lymph node in individuals with recently diagnosed type 1 diabetes.